Lingual squamous cell carcinoma in a California sea lion (Zalophus californianus). |
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| Authors: | Tsuneo Sato Tomomi Higuchi Hisashi Shibuya Shigeo Ohba Sadao Nogami Wataru Shirai Hideaki Watanabe Shigeaki Honda |
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| Affiliation: | Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan. |
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| Abstract: | A 28-yr-old female California sea lion (Zalophus californianus) in a commercial aquarium developed an ulcerated lingual tumor and died. Necropsy revealed a moderately differentiated squamous cell carcinoma. Immunohistochemical staining and electron microscopic studies revealed that the tumor cells were strongly positive with anti-keratin-cytokeratin antibody and had abundant tonofibrils and desmosomes. The neoplasm had metastasized to a mandibular lymph node. |
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