Novel indole C-glycosides from Isatis indigotica and their potential cytotoxic activity |
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Authors: | Wu Yixuan Zhang Zhen-Xue Hu Hui Li Dongmei Qiu Guofu Hu Xianming He Xiangjiu |
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Institution: | a College of Pharmacy, Wuhan University, Wuhan, 430071, Chinab College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, 110142, China |
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Abstract: | Two novel indole C-glycosides, which were the first reported alkaloids C-glycosides from Isatis indigotica, together with five known alkaloids were isolated. The novel alkaloids were elucidated to be indole-3-acetonitrile-4-methoxy-2-C-β-D-glucopyranoside (1) and N-methoxy-indole-3-acetonitrile-2-C-β-D-glucopyranoside (2) on the basis of spectroscopic analysis. 1 exhibited significant cytotoxic activities against human myeloid leukemia HL-60 and human liver cancer HepG2 cells with the IC50 of 1.3 ± 0.1 and 2.1 ± 0.3 μM, respectively. 2 showed potential cytotoxic activities against HL-60 and human myeloid leukemia Mata cells with the IC50 of 5.1 ± 0.4 and 12.1 ± 0.8 μM, respectively. |
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Keywords: | Isatis indigotica Indole C-glycosides Alkaloids Cytotoxic activity |
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