Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue |
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| Authors: | Lam Philip Y Yan Chung Wai Chiu Po Yee Leung Hoi Yan Ko Kam Ming |
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| Affiliation: | Section of Biochemistry and Cell Biology, Division of Life Science, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR, China |
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| Abstract: | Schisandrin B (Sch B) and schisandrin C (Sch C), but not schisandrin A and dimethyl diphenyl bicarboxylate, protected rat skin tissue against solar irradiation-induced oxidative injury, as evidenced by a reversal of solar irradiation-induced changes in cellular reduced glutathione and α-tocopherol levels, as well as antioxidant enzyme activities and malondialdehyde production. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production in rat skin microsomes. Taken together, Sch B or Sch C, by virtue of its pro-oxidant action and the subsequent eliciting of a glutathione antioxidant response, may prevent photo-aging of skin. |
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| Keywords: | Schisandrin Solar radiation Antioxidant Oxidative damage Rat skin |
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