Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice |
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| Authors: | Silva Fábio de Oliveira Silva Maria Goretti de Vasconcelos Feng Dejiang de Freitas Rivelilson Mendes |
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| Institution: | a Laboratório de Produtos Naturais do Departamento de Química da Universidade Federal do Ceará (LPN/UFC), Fortaleza-Ceará, Brazilb Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USAc Programa de Pós-graduação em Ciências Farmacêuticas, Núcleo de Tecnologia Farmacêutica, Laboratório de Pesquisa em Neuroquímica Experimental, Universidade Federal do Piauí (NTF/LAPNEX/UFPI), Teresina, Piauí, Brazil |
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| Abstract: | The depressant and anticonvulsant activities of iso-6-cassine (ISO) from Senna spectabilis (0.5, 1.0 and 1.5 mg/kg) injected by oral route in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to 30 days after the administration and at dose of 1.5 mg/kg, it reduced the remaining time of animals on Rota-rod apparatus. Additionally, ISO at doses tested was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole and picrotoxin. These results suggest possible depressant and anticonvulsant activities in mice that need further investigation. |
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| Keywords: | Senna spectabilis Fabaceae Pentilenotetrazol Picrotoxin Open field |
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