Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat |
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| Authors: | Niu Lingying Qiao Wei Hu Zhendong Li Ning Huang Qian Gong Jianfeng Li Qiurong Zhu Weiming Li Jieshou |
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| Institution: | a School of Medicine, Najing University, Nanjing, Jiangsu 210093, PR Chinab Research Institute of General Surgery, Jinling Hospital, No. 305 East Zhongshan Road, Nanjing, Jiangsu 210002, PR Chinac Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical College, Nanjing, Jiangsu 210008, PR China |
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| Abstract: | Berberine was reported to protect against the intestinal injury and improve the survival rate in sepsis, and glutamine deficiency was considered to be correlated with mortality in sepsis. We found that berberine pretreatment ameliorated lipopolysaccharide-induced direct intestinal injury and mucosal hypoplasia and attenuated impairments of intestinal glutamine transport and glutaminase activity, B0AT1 mRNA and protein expressions, and glutaminase protein expression. These findings showed the first time that berberine pretreatment could improve intestinal recovery and attenuate the impairment of glutamine transport and glutaminase activity in rat sepsis. This might be one of the mechanisms for the beneficial effect of berberine on sepsis. |
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| Keywords: | Berberine Intestine Glutamine B0AT1 Glutaminase Lipopolysaccharide |
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