The effect of safranal on histamine (H1) receptors of guinea pig tracheal chains |
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Authors: | Mohammad Hossein Boskabady Mahbobaeh Ghasemzadeh RahbardarZahra Jafari |
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Institution: | Department of Physiology and Pharmaceutical Research Centre, Medical School Mashhad University of Medical Sciences, Mashhad, Iran |
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Abstract: | The effect of three concentrations of safranal on histamine (H1) receptors was tested on two groups of tracheal chains incubated with: 1) indomethacin, and 2) indomethacin, propranolol and atropine (n = 6). The EC50 (effective concentration of histamine causing 50% of maximum response) obtained in the presence of chlorpheniramine and all concentrations of safranal in both groups were significantly greater than those of saline (p < 0.05 to p < 0.001). The EC50 obtained in the presence of all concentrations of safranal and maximum response of its two higher concentrations (1.25 and 2.5 μg/mL) in group 2 were greater than in group 1 (p < 0.05 to p < 0.001). |
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Keywords: | Safranal Histamine receptor Inhibitory effect Trachea Guinea pig |
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