New diterpenoids and cytotoxic and anti-inflammatory diterpenoids from Amentotaxus formosana |
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| Authors: | Chen Hui-Ling Lin Kai-Wei Gan Kim-Hong Wang Jih-Pyang Won Shen-Jeu Lin Chun-Nan |
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| Institution: | a Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwanb Department of Education and Research, Taichung Veterans General Hospital, Taichung 403, Taiwanc Department of Microbiology and Immunology, National Cheng Kung University, Tainan 701, Taiwand Department of Life Science, National Taitung University, Taitung 950, Taiwan |
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| Abstract: | Two new abietane diterpenoids, ramentoxide (1) and ramentoxidone (2) and a new icetexane diterpenoid, amentonone (3) were isolated from the barks of Amentotaxus formosana. The structures of 1-3 were determined by spectroscopic methods. Known compounds brevitaxin (4), and (+)-ferruginol (5) and ent-kaur-16-en-15-one (6) isolated from this plant revealed potent cytotoxic activity against human breast adenocarcinoma cells, MCF-7 cells with an IC50 value of 0.08 ± 0.05 μg/mL, and significant anti-inflammatory activities, respectively. |
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| Keywords: | Amentotaxus formosana Cytotoxicity Anti-inflammatory activity |
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