| 牛磺鹅去氧胆酸对FLS细胞中GR介导的HSP 90基因表达的影响 |
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| 引用本文： | 宝力格,周蕾,郝大成,朱相成,罗宏亮,李培锋.牛磺鹅去氧胆酸对FLS细胞中GR介导的HSP 90基因表达的影响[J].畜牧与饲料科学,2018,39(8):1-1. |
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| 作者姓名： | 宝力格 周蕾 郝大成 朱相成 罗宏亮 李培锋 |
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| 作者单位： | [1]内蒙古农业大学兽医学院,内蒙古呼和浩特010018;[2]农业部动物临床诊疗技术重点实验室,内蒙古呼和浩特010018;[3]内蒙古金宇保灵生物药品有限公司,内蒙古呼和浩特010030 |
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| 基金项目： | 国家自然科学基金资助项目（31160518）. |
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| 摘 要： | 采用实时荧光定量PCR法分析了牛磺鹅去氧胆酸（taurochenodeoxycholic acid，TCDCA）对佐剂性关节炎模型（adjuvant arthritis，AA）大鼠成纤维滑膜细胞（fibroblast-like synoviocytes，FLS）中由糖皮质激素受体（glucocorticoid receptor，GR）介导的热休克蛋白90基因（heat shock protein 90 gene，HSP90）mRNA表达的影响。结果表明，TCDCA可以极显著性（P〈0.01）下调FLS细胞内HSP 90 mRNA的表达，同时加入GR的特异性抑制剂RU486后可抑制TCDCA对HSP 90 mRNA的作用。由此证明了TCDCA是通过GR受体发挥抗炎和免疫调节作用的。
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Effect of Taurochenodeoxycholic Acid on GR-mediated HSP90 Gene Expression in F LS Cells |
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| Abstract: | The effect of taurochenodeoxycholic acid （TCDCA） on HSP90 mRNA expression mediated by glucocorticoid receptor （GR） in fibroblast-like synoviocytes （FLS） in rats with adjuvant arthritis （AA） was assessed by real-time quantitative PCR assay. The results showed that TCDCA extremely significantly down-regulated the HSP90 mRNA expression in FLS cells （P〈 0.01 ）. In addition, the effect of TCDCA on HSP90 mRNA expression could be inhibited by RU486, a specific inhibitor against GR. It was indicated that TCDCA exerted anti-inflammatory and immunoregulative action via GR. |
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