Mung Bean Decreases Plasma Cholesterol by Up-regulation of CYP7A1 |
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| Authors: | Yang Yao Liu Hao Zhenxing Shi Lixia Wang Xuzhen Cheng Suhua Wang Guixing Ren |
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| Institution: | 1. Institute of Crop Science, Chinese Academy of Agricultural Sciences, No.80 South Xueyuan Road, Haidian District, Beijing, 100081, People’s Republic of China
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| Abstract: | Our results affirmed that supplementation of 1 or 2 % mung bean could decrease plasma total cholesterol and triacylglycerol level. Mung bean increased mRNA 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase. Most importantly, mung bean increased not only the protein level of cholesterol-7α-hydroxylase (CYP7A1) but also mRNA CYP7A1. It was concluded that the hypocholesterolemic activity of mung bean was most probable mediated by enhancement of bile acid excretion and up-regulation of CYP7A1. |
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