国产咪唑苯脲对小鼠和水牛人工感染伊氏锥虫病的治疗试验

应用国产咪唑苯脲,以0.5mg、0.75mg两种剂量及1、2、3 d不同疗程,对人工感染伊氏锥虫的小鼠进行了治疗试验。结果,0.75mg×2 d组连续观察15 d以上,大多数小鼠存活,而未经治疗的对照组小鼠全部死亡。对3头人工感染伊氏锥虫的水牛,以4 mg/kg剂量一次皮下注射治疗后24 h,血液压滴标本检查虫体阴性,但1周后集虫检查和小鼠接种试验均为阳性,后改用3mg/kg×2d疗法,全部治愈。另外3头人工感染伊氏锥虫的水牛,以3mg/kg×2d疗法治疗后,用血液压滴法,集虫法及小鼠接种法检查虫体均为阴性,连续观察3个月未见复发。

Using Domestic Imidocarb to Treat Mice and Buffaloes Experimentally Infested with Trypanosoma evansi

Domestic imidocarb was used to treat mice and buffaloes artificially infested with Trypanosoma evansi. The treatment schedule for mice was 1, 2 or 3 daily doses of 0.5mg or 0.75 mg by subcutaneous injection and for buffaloes a single dose of 4mg or 2 daily doses of 3 mg per kg of body weight. The trial results showed that most of the mice administered 2 daily doses of 0.75mg survived and three infested buffaloes receiving 2 daily doses of 3 mg/kg body weight have recovered and no relapse was seen during the subsequent observation period of 3 months.