Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice |
| |
Authors: | Hosseinzadeh Hossein Talebzadeh Fatemeh |
| |
Institution: | Pharmaceutical Research Center, Faculty of Pharmacy, Mashad University of Medical Sciences, Mashhad, Iran. hosseinzadehh@mums.ac.ir |
| |
Abstract: | The anticonvulsant activities of Crocus sativus stigma constituents, safranal and crocin, were evaluated in mice using pentylenetetrazole (PTZ)-induced convulsions in mice. Safranal (0.15 and 0.35 ml/kg, i.p.) reduced the seizure duration, delayed the onset of tonic convulsions and protected mice from death. Crocin (200 mg/kg, i.p.) did not show anticonvulsant activity. |
| |
Keywords: | Crocus sativus Safranal Crocin Anticonvulsant |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|