Active mammary excretion of N4-acetylated p-aminohippuric acid |
| |
Authors: | F Rasmussen |
| |
Affiliation: | Department of Pharmacology and Toxicology, The Royal Veterinary and Agricultural University, Copenhagen, Denmark |
| |
Abstract: | Different excretion patterns were observed for p-amino- hippuric acid and its acetylated metabolite in mammary excretion experiments in goats and cows. The excretion of p-aminohippuric acid conformed to passive diffusion of the non-protein bound and un-ionized fraction (Rasmussen 1958, 1966) as described by Miller et al. (1967). Thus, the p-aminohippuric acid (pKa 3.8) appeared in ultrafiltrates of milk in concentrations 1/4—1/10 of the concentrations in ultrafiltrates of blood plasma. The concentrations of acetylated p-aminohippuric acid (pKa 3.9) in ultrafiltrates of milk were on the other hand equal to or higher than in ultrafiltrates of blood plasma. |
| |
Keywords: | |
|
|