氨苄西林混悬液对鸡大肠杆菌病的药效研究

［目的］评价氨苄西林混悬液对鸡大肠杆菌病的疗效，为临床合理用药提供依据。［方法］以科宝肉鸡为研究对象，通过体外和体内抑菌试验研究了用氨苄西林混悬液防治鸡大肠杆菌病的疗效，并与氨苄西林可溶性粉进行了对比。［结果］体外抑菌试验结果表明：氨苄西林混悬液和氨苄西林可溶性粉对大肠杆菌的最小抑菌浓度分别为1 μg/ml和4 μg/ml；体内抑菌试验中，氨苄西林混悬液各组的死亡率明显低于阳性对照组，统计学差异显著（P〈0.05）或极显著（P〈0.01）。在治疗效果上，氨苄西林混悬液各组与氨苄西林可溶性粉各组比较，治愈率和有效率显著提高，死亡率明显降低，但均无统计学差异；在增重效果上，氨苄西林混悬液各组与阳性对照组比较差异极显著（P〈0.01），与阴性对照组比较差异显著（P〈0.05）或极显著（P〈0.01），与氨苄西林可溶性粉各组比较差异显著（P〈0.05）。［结论］氨苄西林混悬液可用于防治鸡大肠杆菌病，预防量以30 mg/L，治疗剂量为90 mg/L为最佳。

Efficacy of Ampicillin Suspension against Colibacillosis in Chicken

[Objective] The research aimed to evaluate the curative effect of Ampicillin suspension against the chicken infected by coliform,and provide basis for clinical rational drug use.[Methods]The curative effect of Ampicillin suspension was tested in preventing the colibacillosis in Kebao Chicken through in vitro and in vivo experiments,and was compared the result with Ampicillin soluble powder.[Results]Vitro test results showed that:the minimal inhibitory concentration of E.coli by Ampicillin suspension and Amp...