Effect of Bacopa monniera Linn. (brahmi) extract on learning and memory in rats: A behavioral study |
| |
| Authors: | Venkata Ramana Vollala Subramanya Upadhya Satheesha Nayak |
| |
| Institution: | 1. Department of Anatomy, Melaka Manipal Medical College (Manipal Campus), Manipal University, Manipal;2. Department of Physiology, St. George''s University School of Medicine, Grenada, West Indies;1. Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea;2. East-West Medical Research Institute, Kyung Hee University Medical Center, Seoul 130-701, Republic of Korea;3. Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea;4. Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 604-714, Republic of Korea;5. Institute of Convergence Bio-Health, Dong-A University, Busan 604-714, Republic of Korea;1. Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India;2. National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305 8562, Japan;1. Department of Pharmacognosy, School of Pharmaceutical Sciences, IFTM University, Moradabad 244001, India;2. Department of Pharmaceutical Sciences, Birla Institute of Technology, Ranchi 835215, India;1. Department of Mathematics, Faculty of Science, Mansoura University, Mansoura 35516, Egypt;2. Department of Mathematics, Faculty of Science, King Faisal University, P.O. Box 400, Al-Ahsaa 31982, Saudi Arabia |
| |
| Abstract: | Extracts of Bacopa monniera (Brahmi, BM), a traditional ayurvedic medicine, have been reported to have memory-enhancing effects in animals. However, there are no studies in which different dosages or chronic use have been explored. The current study examined the effects of standardized extract of BM on behavioral changes of Wistar rats when administered the extract for various durations and in varying doses. We divided the animals into 2-, 4-, and 6-week treatment groups. Rats in each of these groups were divided into 20 mg/kg, 40 mg/kg, and 80 mg/kg dose groups (n = 8 for each dose). After the treatment period, the rats, along with age-matched normal and gum acacia control rats, were subjected to spatial learning (T-maze) and passive avoidance tests. The data were compared with those of age-matched control rats. The study was conducted at the Melaka Manipal Medical College, Manipal University, Manipal, Karnataka, India. The results showed improvement in spatial learning performance and enhanced memory retention in rats treated with BM extract. These results clearly indicate that oral administration of BM extract improved learning and memory in rats. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
