Effect of clomipramine on the electrocardiogram and serum thyroid concentrations of healthy cats |
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| Authors: | Kenneth M Martin |
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| Institution: | 1. Lincoln Land Animal Clinic, LTD, Jacksonville, Illinois;2. University of Illinois College of Veterinary Medicine, Chicago, Illinois;3. Ceva Animal Health, LLC, Sweetwater, Texas;4. Jacksonville, Illinois;1. Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium;2. Department of Comparative Physiology and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium;1. Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina;2. Department of Statistics, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina;1. Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;2. Zoetis, Medical Affairs, Parsippany, New Jersey, USA;3. Orion Corporation, Research and Development, Espoo, Finland;4. Department of Clinical Sciences, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, USA;1. School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia;2. Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia;1. Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio;2. Department of Veterinary Preventive Medicine, The Ohio State University College of Veterinary Medicine, Columbus, Ohio;3. The Ohio State University College of Veterinary Medicine, Columbus, Ohio |
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| Abstract: | Clomipramine is a tricyclic antidepressant (TCA) commonly used to treat anxiety related behavioral disorders in companion animals. Tricyclic antidepressants (TCAs) have the potential to cause arrhythmias in humans and companion animals. The effect of the TCAs, clomipramine, and amitriptyline, at therapeutic dosages on cardiac rhythm has been evaluated in dogs. The effect of clomipramine on the cardiac rhythm of cats has not been reported. In Experiment 1, 7 healthy cats were selected to evaluate the effect of clomipramine on their cardiac rhythm using an electrocardiogram. A baseline electrocardiogram was carried out before (Day 0) and repeated (Day 29) after 4 weeks (28 days) of daily clomipramine (10 mg/cat PO) administration. Significant changes in the electrocardiogram were not found after 28 days of daily clomipramine administration. In Experiment 2, 7 healthy cats were enrolled in the study to evaluate the effect of clomipramine administration on the serum thyroid concentrations in cats. Clomipramine (10 mg/cat PO daily) was administered to all cats beginning on Day 1, and continued for 28 days. Serum total thyroxine (T4), triiodothyronine (T3), and free thyroxine (fT4) concentrations were measured before (Day 0) and repeated (Day 29) after 4 weeks (28 days) of daily clomipramine administration. Statistically significant decreases in serum thyroid concentrations (T4, T3, and fT4) were noted between pre and post clomipramine administration. A decrease of 25, 24, and 16% in serum T4, T3, and fT4 concentrations, respectively, may lead to a misdiagnosis of euthyroidism in a subclinical hyperthyroid patient. A longer duration of drug treatment might further suppress thyroid function when used as a single agent, with concomitantly administered drugs, or in conjunction with euthyroid sick syndrome. |
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