Some pharmacokinetic data about furaltadone and nitrofurazone administered orally to preruminant calves |
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Authors: | J F Nouws T B Vree M M Aerts M Degen F Driessens |
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Institution: | Department of Clinical Pharmacy, Sint Radboud Hospital, Nijmegen, The Netherlands. |
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Abstract: | A single oral dosage of furaltadone and nitrofurazone (14.0 mg/kg) to 5 preruminant calves (in a cross-over trial) revealed mean maximum plasma concentration of 2.5 and 3.5 microgram/ml, respectively, at approximately 3 h after administration. The final elimination half-lives of furaltadone and nitrofurazone were 2.5 and 5 h, respectively. Urinary recovery of these two nitrofurans in 3 calves revealed approximately 2% of the orally administered dose. The renal clearance of the unbound drugs did not differ (for both drugs approximately 0.42 ml/min/kg); furaltadone clearance was strongly related to urine flow. |
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