102中草药复方制剂的毒性试验

采用灌胃和腹腔注射的方法，对１０２中草药复方制剂进行了急性毒性试验和亚急性毒性试验，结果表明，该制剂水提物给小白鼠灌胃，其毒副作用很小，耐受量大于１ｍＬ／１０ｇ，４５ｄ后，小白鼠体重明显增加，与对照组相比差异显著，心、肝、脾、胃、肾作组织学检查，未民两全是变化，给小白鼠腹腔注射，该制剂有毒性，ＬＤ５０为０．５４５ｍｌ／１０ｇ，故该制剂水提物不宜腹腔注射给药。

Studies of Toxicity on the Compound Perparation of 102 Chines e Medicinal Herbs

Acute toxicity and subchronic toxicity tests were conducted on the compound preparation of 102 Chinese medicinal herbs by using the methods of peros and intraperitioneal injection.The results show that the tolerable amount is over 1 mL/10 g body weight when the mice are perused the compound preparation;after 45 d,the weight of mice increases significatly compared with the control.No histopathology is found in the hearts,livers spleens,stomaches,kidneys of the mice.The preparation is toxic when a intraperitioneal injection is given to the mice;and LD 50 is 0.545 mL/10 g,so aqueous extract of the preparation is unsuitable for the mice by way of intraperitioneal injection.