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The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus |
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| Authors: | Kasumi SUDO Manabu YAMADA Mariko OCHIAI Shoko IWAMOTO Hajime SAKAKI Chiho KUSHIDA Maiko YAMASHITA Atsushi YAMAMOTO Takao NAGASAKA Mikio OIDEMIZU Akito SAITO Kinya YAMAMOTO |
| Institution: | 1)National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan;2)National Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannodai, Tsukuba, Ibaraki 305-0856, Japan;3)Present address: Food and Agriculture Organization of the United Nations, Viale delle Terme di Caracalla, 00153 Rome, Italy |
| Abstract: | We evaluated the role of classical swine fever virus (CSFV) in the formation of button ulcers in the mucosa of the gastrointestinal tract. Histopathological and immunohistochemical analyses of pigs experimentally infected with a subgenotype 2.1 isolate of CSFV, which was isolated in Japan in 2019, revealed follicular necrosis in the submucosal mucosa-associated lymphoid tissue and herniation of crypts as factors that contribute to the development of button ulcers during CSFV infection. These findings indicate that CSFV induces follicular necrosis and is one of the causative agents of button ulcers in pigs. |
| Keywords: | button ulcer classical swine fever virus herniation of crypt histopathology |