New cembranolides from the Dongsha Atoll soft coral Lobophytum durum |
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Authors: | Cheng Shi-Yie Chen Pei-Wen Chen Hwa-Pyng Wang Shang-Kwei Duh Chang-Yih |
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Institution: | Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. |
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Abstract: | Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M–Q (1–5). The structures of compounds 1–5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC50 of 5.2 μg/mL. |
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Keywords: | soft coral Lobophytum durum cytotoxicity antiviral activity |
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