T cell activation by lipopeptide antigens |
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Authors: | Moody D Branch Young David C Cheng Tan-Yun Rosat Jean-Pierre Roura-Mir Carme O'Connor Peter B Zajonc Dirk M Walz Andrew Miller Marvin J Levery Steven B Wilson Ian A Costello Catherine E Brenner Michael B |
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Institution: | Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA. bmoody@rics.bwh.harvard.edu |
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Abstract: | Unlike major histocompatibility proteins, which bind peptides, CD1 proteins display lipid antigens to T cells. Here, we report that CD1a presents a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. T cell activation was mediated by the alphabeta T cell receptors and was specific for structure of the acyl and peptidic components of these antigens. These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity. |
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