Adenosine 3',5'-monophosphate in pancreatic islets: glucose-induced insulin release |
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Authors: | M A Charles R Fanska F G Schmid P H Forsham G M Grodsky |
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Abstract: | Glucose-induced release of insulin from perifused rat islets is associated with elevated islet adenosine 3',5'-monophosphate. If values for adenosine 3',5'-monophosphate are compared to insulin release during theophylline or glucose stimulation and theophylline plus glucose stimulation, it suggests a minor role for adenosine 3',5'-monophosphate in directly stimulating insulin release but a prominent role in modulating glucose-induced release of insulin. |
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