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Caffeine clearance in the horse |
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| Authors: | J Schumacher J S Spano R C Wilson F J DeGraves S H Duran D C Ruffin |
| Institution: | (1) Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, 36849-5522, AL, USA;(2) Department of Pathobiology, College of Veterinary Medicine, Auburn University, 36849-5522, AL, USA;(3) Department of Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, 36849-5522, AL, USA |
| Abstract: | The pharmacokinetic properties of intravenously administered caffeine were studied in 10 horses using a commercially available automated enzyme immunoassay. The harmonic mean for the distribution half-life was 5.2 min (range 1.4–18.7). The harmonic mean for the elimination half-life was 10.18 h (range 6.82–20.92). The harmonic mean of the volume of distribution was 0.32 L/kg (range 0.22–0.53). There was no correlation between the dose of caffeine/kg body weight and the elimination half-life (Spearman's coefficient of rank correlation =0.19).Abbreviations AUC
area under the serum concentration-time curve
- AUMC
area under the moment curve
- BSP
sulphobromophthalein
- ICG
indocyanine green
- SD
standard deviation
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t
1/2
elimination half-life
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V
c
apparent volume of the central compartment
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V
d(ss)
apparent volume of distribution at steady state |
| Keywords: | caffeine horse liver function pharmacokinetics |
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