Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii |
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Authors: | Raible Florian Tessmar-Raible Kristin Osoegawa Kazutoyo Wincker Patrick Jubin Claire Balavoine Guillaume Ferrier David Benes Vladimir de Jong Pieter Weissenbach Jean Bork Peer Arendt Detlev |
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Institution: | Developmental Unit, European Molecular Biological Laboratory (EMBL), Meyerhofstrasse 1, D-69117 Heidelberg, Germany. raible@embl.de |
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Abstract: | Previous genome comparisons have suggested that one important trend in vertebrate evolution has been a sharp rise in intron abundance. By using genomic data and expressed sequence tags from the marine annelid Platynereis dumerilii, we provide direct evidence that about two-thirds of human introns predate the bilaterian radiation but were lost from insect and nematode genomes to a large extent. A comparison of coding exon sequences confirms the ancestral nature of Platynereis and human genes. Thus, the urbilaterian ancestor had complex, intron-rich genes that have been retained in Platynereis and human. |
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