| 1-苯并环庚酮的简便合成研究 |
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| 引用本文： | 高磐龙,孙小强,邱太源. 1-苯并环庚酮的简便合成研究[J]. 安徽农业科学, 2010, 38(19): 9948-9949. DOI: 10.3969/j.issn.0517-6611.2010.19.006 |
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| 作者姓名： | 高磐龙 孙小强 邱太源 |
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| 作者单位： | 江苏工业学院化学化工学院,江苏常州,213164;常州元朔化工科技有限公司,江苏常州,213164 |
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| 摘 要： | [目的]考察了1-苯并环庚酮的合成路线。[方法]以1-溴-3-苯基丙烷和丙二酸二乙酯为原料,通过取代反应,制得2-（3-苯丙基）丙二酸,对其加热脱羧得到中间体5-苯基正戊酸,再用多聚磷酸（PPA）环化脱水生成1-苯并环庚酮。[结果]反应总收率达52.9%～61.0%。用IR,1HNMR及MS对中间体、最终产物进行了表征。[结论]该方法操作简便,反应收率高,为1-苯并环庚酮的合成提供了一条经济路线。
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| 关 键 词： | 1-苯并环庚酮 5-苯基正戊酸 合成 |
Convenient Synthesis of 1-Benzosuberone |
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| GAO Pan-long et al. Convenient Synthesis of 1-Benzosuberone[J]. Journal of Anhui Agricultural Sciences, 2010, 38(19): 9948-9949. DOI: 10.3969/j.issn.0517-6611.2010.19.006 |
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| Authors: | GAO Pan-long et al |
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| Affiliation: | GAO Pan-long et al(Department of Chemical Engineering,Jiangsu Polytechnic University,Changzhou,Jiangsu 213164) |
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| Abstract: | [Objective] The purpose of this research was to study the synthesis of 1-benzosuberone.[Method] The cyclodehydration of 5-phenylvaleric acid prepared from 1-bromo-3-phenylpropane and diethyl malonate by substitution reaction to give 2-(3-phenylpropyl)-malonic acid which was subjected by decarboxylation with heating,with polyphosphoric acid afforded 1-benzosuberone.[Result] The overall yield was 52.9%-61.0%.Structures of the intermediates and the final product were characterized by IR,NMR and MS.[Conclusion]... |
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| Keywords: | 1-benzosuberone 5-phenylvaleric acid Synthesis |
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