Protection against Brucellosis in Goats,Five Years after Vaccination with Reduced-Dose Brucella melitensis Rev 1 Vaccine |
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Authors: | Díaz-Aparicio E. Hernández L. Suárez-Güemes F. |
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Affiliation: | CENID Microbiología, Instituto Nacional de Investigaciones Agrícolas, Forestales y Pecuarias, Carretera Federal México-Toluca Km. 15.5, Cuajimalpa, Mexico. diaz@ciml.univ-mrs.fr |
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Abstract: | The protection conferred by the reduced-dose Rev 1 Brucella melitensis vaccine in goats that had been immunized 5 years previously was evaluated. Sixteen goats vaccinated 5 years before with Rev 1 (1 x 10(5) cfu) and 5 non-vaccinated goats were challenged with B. melitensis 16M (4 x 10(5) cfu) using the conjunctival route. After giving birth or aborting, the goats were sacrificed and tissue samples were taken for bacteriological study. The challenge strain was recovered in 12%, of the animals from the vaccinated group, and in (80% of the control group. It is concluded, therefore that the use of reduced-dose Rev 1 protects goats vaccinated in endemic areas for at least 5 years after immunization. |
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Keywords: | Brucella melitensis brucellosis goats Mexico Rev 1 |
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