CNS activities of methanolic extract of Moringa oleifera root in mice |
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| Affiliation: | 166121. Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India;1. School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China;2. Institute of Advanced Materials, School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China;3. Key Laboratory of Systems Bioengineering of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;1. National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia;2. School of Medicine, University of Tasmania, Tasmania, Australia;3. Sydney Medical School, Sydney University, New South Wales, Australia;4. Drug and Alcohol Services, South East Sydney Local Health District, New South Wales, Australia;5. University of Adelaide, South Australia, Australia;1. Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark;2. Nutrition and Food Science Area, Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Faculty of Pharmacy, Universitat de València, Avda. Vicent Andrés Estellés, s/n, 46100, Burjassot, València, Spain;1. Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark;1. Lectorate, Department of Anatomy, Guangdong Medical College, Zhanjiang, China;2. Resident-in-Training, Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;3. Professor and President, Department of Microsurgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;4. Professor, Department of Anatomy, Zhong Shan School of Medicine, Sun Yat-sen University, Guangzhou, China;1. Department of Pharmacology & Molecular Therapeutics, Nanchang University School of Pharmaceutical Science, Nanchang 330006, PR China;2. Jiangxi Provincial Key Laboratory of Molecular Medicine at the Second Affiliated Hospital, Nanchang University, Nanchang 330006, PR China |
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| Abstract: | Methanolic extract (ME) of the root of Moringa oleifera was tested for possible pharmacological effects on experimental animals. ME potentiated significantly the sleeping time induced by pentobarbitone sodium, diazepam and meprobamate, showed analgesic properties and also potentiated analgesia induced by morphine and pethidine. Pretreatment with ME caused significant protection against strychnine- and leptazol-induced convulsions. The behavioural studies on mice indicate the CNS depressant nature of ME. |
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