Role of Bibersteinia trehalosi, respiratory syncytial virus,and parainfluenza-3 virus in bighorn sheep pneumonia |
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| Authors: | Rohana P Dassanayake Sudarvili Shanthalingam Renuka Subramaniam Caroline N Herndon Jegarubee Bavananthasivam Gary J Haldorson William J Foreyt James F Evermann Lynn M Herrmann-Hoesing Donald P Knowles Subramaniam Srikumaran |
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| Institution: | 1. Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA;2. Washington Animal Disease Diagnostic Laboratory, Washington State University, Pullman, WA 99164-7040, USA;3. Animal Disease Research Unit, USDA Agricultural Research Service, Washington State University, Pullman WA 99164-6630, USA |
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| Abstract: | Pneumonic bighorn sheep (BHS) have been found to be culture- and/or sero-positive for Bibersteinia trehalosi, respiratory syncytial virus (RSV), and parainfluenza-3 virus (PI-3). The objective of this study was to determine whether these pathogens can cause fatal pneumonia in BHS. In the first study, two groups of four BHS each were intra-tracheally administered with leukotoxin-positive (Group I) or leukotoxin-negative (Group II) B. trehalosi. All four animals in Group I developed severe pneumonia, and two of them died within 3 days. The other two animals showed severe pneumonic lesions on euthanasia and necropsy. Animals in Group II neither died nor showed gross pneumonic lesions on necropsy, suggesting that leukotoxin-positive, but not leukotoxin-negative, B. trehalosi can cause fatal pneumonia in BHS. |
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| Keywords: | Bighorn sheep Pneumonia Bibersteinia trehalosi Mannheimia haemolytica Respiratory syncytial virus Parainfluenza-3 virus |
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