Septicaemic Escherichia coli and experimental infection of calves |
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| Authors: | M Contrepois H C Dubourguier A L Parodi J P Girardeau J L Ollier |
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| Affiliation: | 1. Laboratoire de Microbiologie, I.N.R.A. - C.R.Z.V. de Theix, 63122 Ceyrat France;2. Laboratoire d''Histologie et d''Anatomie Pathologique, Ecole Nationale Vétérinaire d''Alfort, 7, avenue du Général de Gaulle, 94704 Maisons-Alfort Cedex France;1. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;2. Institute of Molecular Virology (IMV), University of Muenster, Muenster 48149, Germany;3. Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;4. Department of Veterinary Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;5. Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA;6. Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN 38103, USA;1. Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania;2. HCA (Hospital Corporation of America) West Florida/Largo Medical Center, Largo, Florida;3. Western University Health Services, Orange County, California;3. Inflammation Immunobiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892;4. Molecular Signal Transduction Sections, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892;5. Department of Biology, Creighton University, Omaha, Nebraska 68178;6. Department of Biochemistry and Molecular Biology, Division of Pulmonary Medicine, Mayo Clinic, Scottsdale, Arizona 85259;1. Laboratório de Virologia Aplicada, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, Brazil;2. Grupo de Estudos em Saneamento Descentralizado, Departamento de Engenharia Sanitária e Ambiental, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, Brazil;3. Laboratório de Ecologia de Águas Continentais, Departamento de Ecologia e Zoologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário s/n, Trindade, Florianópolis, SC CEP. 88040-970, Brazil |
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| Abstract: | Three strains of Escherichia coli with a common surface antigen, 31a, capable of adhering to calf enterocytes in vitro were compared to reference strains of septicaemic E. coli (RVC 330 and vir E. coli). The surface antigen 31a was present in the RVC 330 reference strain. E. coli vir had a surface antigen which was not present in E. coli 31a or E. coli RVC 330. The RVC 330 and vir reference strains also adhered to calf enterocytes in vitro. Oral infection of calves not receiving colostrum with E. coli 31a was generally followed by septicaemia and death in less than 48 h. Post-mortem examination revealed pneumonia and oedema of the kidneys and gall bladder. Oral infection of calves receiving colostrum had no effect, but intravenous inoculation produced arthritis within 15 days. The comparison of these results with those previously described by other workers did not lead to the identification of pathognomonic characteristics, which could be clearly correlated with properties specific to E. coli 31a. It is suggested that, like ColV and vir, antigen 31a may be a virulence marker for certain strains of bovine septicaemic E. coli. Furthermore, the 31a antigen appears to be carried on a plasmid. |
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