Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4 |
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Authors: | P T Golumbek A J Lazenby H I Levitsky L M Jaffee H Karasuyama M Baker D M Pardoll |
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Affiliation: | Department of Medicine, Johns Hopkins University, Baltimore, MD 21205. |
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Abstract: | The generation of antigen-specific antitumor immunity is the ultimate goal in cancer immunotherapy. When cells from a spontaneously arising murine renal cell tumor were engineered to secrete large doses of interleukin-4 (IL-4) locally, they were rejected in a predominantly T cell-independent manner. However, animals that rejected the IL-4-transfected tumors developed T cell-dependent systemic immunity to the parental tumor. This systemic immunity was tumor-specific and primarily mediated by CD8+ T cells. Established parental tumors could be cured by the systemic immune response generated by injection of the genetically engineered tumors. These results provide a rationale for the use of lymphokine gene-transfected tumor cells as a modality for cancer therapy. |
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