| 子宫内膜异位症大鼠模型复制 |
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| 引用本文： | 刘爱红,戴淑真,姚琴,李健. 子宫内膜异位症大鼠模型复制[J]. 动物医学进展, 2005, 26(2): 89-92 |
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| 作者姓名： | 刘爱红 戴淑真 姚琴 李健 |
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| 作者单位： | 青岛大学医学院附属医院,山东青岛,266003;青岛大学医学院附属医院,山东青岛,266003;青岛大学医学院附属医院,山东青岛,266003;青岛大学医学院附属医院,山东青岛,266003 |
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| 摘 要： | 取Wistar大鼠30只,用手术移植的 方法把自体子宫内膜组织2块分别移植到壁 腹膜与子宫系膜处,建立子宫内膜异位症大 鼠模型。术后4周,再次开腹,观察异位内膜 的存活情况、与周围组织的粘连程度及病理 学变化。结果发现腹膜和子宫系膜处移植内 膜的成活率及病灶的体积差异无显著性(P >0.05),腹膜处病灶与周围组织的粘连程度 显著轻于子宫系膜处病灶(P<0.01),移植 物外观呈囊状,表面有血管,光镜下观察见子 宫内膜细胞、间质细胞、腺体和血管,与正常 在位内膜相比腺体减少。该模型复制方法简 便,成功率高,是研究子宫内膜异位症较理想 的动物模型。
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| 关 键 词： | 子宫内膜异位症 模型 Wistar大鼠 |
| 文章编号： | 1007-5038(2005)02-089-04 |
| 修稿时间： | 2004-08-18 |
A Rat Model of Endometriosis |
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| LIU Ai-hong,DAI Shu-zhen,Yao Qin,Qin LI Jian. A Rat Model of Endometriosis[J]. Progress In Veterinary Medicine, 2005, 26(2): 89-92 |
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| Authors: | LIU Ai-hong DAI Shu-zhen Yao Qin Qin LI Jian |
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| Abstract: | The endomerium tissue squares of Wistar rats were autotransplanted to the surface of the peritoneum and mesometrium,then pathological changes were observed after 4 weeks.We found that difference was not significant in the survival rate and the volume between implant on the peritoneum and that on the mesometrium (P>0.05).Adhesions of implant on the peritoneum to celiac tissues were lighter than that on the mesometrium (P<0.01).The endometrial implants in the rats became cystic structures that were composed by endometrial gland and stroma,and the macroscopic and histologic appearance was consistent with endometriosis. Conclusion was that the autotransplanted surgically rat model of endometriosis would grow stably with easy success and it could be an ideal animal model for reasearohing EMT. |
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| Keywords: | endometriosis models wistar rat |
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