A comparison between the efficacy of thiabendazole and febantel on experimental trichinellosis in rats |
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| Authors: | H A Alcaíno T R Gorman M B Elorrieta |
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| Institution: | School of Veterinary Sciences, University of Chile, Casilla 49 Correo 15, Santiago, Chile |
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| Abstract: | Febantel at a dose level of 5 mg kg-1 had a lethal efficacy of 54.1% against the adult worm and 69.5% against the migrating larvae of Trichinella spiralis in rats. When administered at 15 mg kg-1, it demonstrated lethal effects of 94.4, 92.5 and 74.7% against adult, young and encysted larvae, respectively. Infected rats treated with 300 mg kg-1 died. Thiabendazole had efficiencies of 96.4 and 83.3% against intestinal and migrating early muscle phases, respectively, and was 42% effective against the encysting phase. |
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