Pharmacokinetics of benzydamine in dairy cows following intravenous or intramuscular administration |
| |
Authors: | P. Anfossi J. Malvisi N. Catraro M. Bolognini L. Tomasi G. L. Stracciari |
| |
Affiliation: | (1) Istituto di Farmacologia, Farmacocinetica e Tossicologia, Facoltà di Medicina Veterinaria, Università degli Studi di Bologna, Via Tolara di Sopra, 40064 Ozzano Emilia (BO), Italy;(2) Cattedra di Farmacologia, Farmacodinamica e Farmacia Veterinaria, Facoltà di Medicina Veterinaria, Università degli Studi di Perugia, Via S. Costanzo, 4, Perugia (PG), Italy;(3) Aziende Chimiche Riunite Angelini Francesco, Divisione Veterinaria, S.S. 16 Adriatica km 303, Ancona (AN), Italy;(4) Practitioner, Via Jacopo della Quercia, 36, Padova (PD), Italy |
| |
Abstract: | Five lactating cows were given benzydamine hydrochloride by rapid intravenous (0.45 mg/kg) and by intramuscular (0.45 and 1.2 mg/kg) injection in a crossover design. The bioavailability, pharmacokinetic parameters and excretion in milk of benzydamine were evaluated. After intravenous administration, the disposition kinetics of benzydamine was best described using a two-compartment open model. Drug disposition and elimination were fast (t1/2 : 11.13±3.76 min;t1/2 : 71.98±24.75 min; MRT 70.69±11.97 min). Benzydamine was widely distributed in the body fluids and tissues (Vd(area): 3.549±1.301 L/kg) and characterized by a high value for body clearance (33.00±5.54 ml/kg per min). After intramuscular administration the serum concentration-time curves fitted a one-compartment open model. Following a dose of 0.45 mg/kg, theCmax value was 38.13±4.2 ng/ml at atmax of 67.13±4.00 min; MAT and MRT were 207.33±22.64 min and 278.01±12.22 min, respectively. Benzydamine bioavailability was very high (92.07%±7.08%). An increased intramuscular dose (1.2 mg/kg) resulted in longer serum persistence (MRT 420.34±86.39 min) of the drug, which was also detectable in milk samples collected from both the first and second milking after treatment.Abbreviations HPLC high-pressure liquid chromatography - IC50 concentration to inhibit the activity of an organism by 50% - IM intramuscular(ly) - IV intravenous(ly) - NSAID non-steroidal antiinflammatory drugs - pKa negative logarithm of the ionization constant (Ka) of a drug; other abbreviations are listed in footnotes to tables |
| |
Keywords: | benzydamine bioavailability cattle milk pharmacokinetics |
本文献已被 SpringerLink 等数据库收录! |
|