| 亚慢性铝暴露对雏鸡大脑组织氨基酸类神经递质的影响 |
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| 引用本文： | 夏士亮,刘红强,韩彦飞,佘玥,李艳飞.亚慢性铝暴露对雏鸡大脑组织氨基酸类神经递质的影响[J].中国家禽,2011,33(23). |
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| 作者姓名： | 夏士亮 刘红强 韩彦飞 佘玥 李艳飞 |
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| 作者单位： | 东北农业大学动物医学学院,黑龙江哈尔滨,150030 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目，国家自然科学基金项目 |
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| 摘 要： | 以1周龄海兰白蛋鸡为试验对象,采用连续腹腔注射等体积不同浓度梯度AlC13的方法,建立不同程度亚慢性铝暴露模型,研究铝暴露对鸡大脑组织氨基酸类神经递质的影响.试验雏鸡分为对照、低、中、高4个试验组,铝暴露剂量分别为0、18.31、27.47、36.62 mg/kg·dAl3+,暴露60 d后,用高效液相色谱(HPLC)法检测鸡大脑组织中氨基酸类神经递质含量,原子吸收分光光度法检测鸡血清和大脑组织中铝的含量.结果表明,随染铝剂量的加大,谷氨酸( Glu)的含量呈升高趋势,但与对照组相比差异不显著(P＞0.05)；血清和大脑组织中铝的含量、甘氨酸(Gly)、γ-氨基丁酸(GABA)、牛磺酸(Tau)含量均高于对照组,与对照组比较差异显著(P＜ 0.05；P＜0.01)；低剂量组天门冬氨酸(Asp)含量低于对照组,中高剂量组高于对照组,与对照组比较差异显著(P＜ 0.05；P＜0.01).结果提示,铝暴露可通过影响雏鸡氨基酸类神经递质的含量而产生兴奋性神经毒性作用.
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| 关 键 词： | 铝 鸡 大脑 氨基酸类神经递质 |
Effects of Sub-chronic Aluminum Exposure on Amino Acids Neurotransmitter in Chicken Brain |
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| XIA Shiliang,LIU Hongqiang,HAN Yanfei,SHE Yue,LI Yanfei.Effects of Sub-chronic Aluminum Exposure on Amino Acids Neurotransmitter in Chicken Brain[J].China Poultry,2011,33(23). |
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| Authors: | XIA Shiliang LIU Hongqiang HAN Yanfei SHE Yue LI Yanfei |
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| Institution: | XIA Shiliang,LIU Hongqiang,HAN Yanfei,SHE Yue,LI Yanfei(College of Veterinary Medicine,Northeast Agricultural University,Harbin,Heilongjiang 150030) |
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| Abstract: | The one-week-age Hy-line white laying hens with different level subchronic aluminum(Al) intoxication was produced by continuous peritoneal injection of fixed volume and different concentration gradient of aluminum trichloride. Different level sub-chronic Al exposure model was built successfully. The content of amino acids neurotransmitter in the chicken brain tissue was detected by high performance liquid chromatography(HPLC) after being exposured for 60 days to investigate effects of Al exposure on amino a... |
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| Keywords: | aluminum chicken chicken brain amino acids neurotransmitter |
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