Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae |
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| Authors: | Noel M Lacerna II Cydee Marie V Ramones Jose Miguel D Robes Myra Ruth D Picart Jortan O Tun Bailey W Miller Margo G Haygood Eric W Schmidt Lilibeth A Salvador-Reyes Gisela P Concepcion |
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| Institution: | 1.The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines; (N.M.I.II); (C.M.V.R.); (J.M.D.R.); (M.R.D.P.); (J.O.T.); (L.A.S.-R.);2.Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA; (B.W.M.); (M.G.H.); (E.W.S.) |
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| Abstract: | The bioactivity-guided purification of the culture broth of the shipworm endosymbiont Teredinibacter turnerae strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid (1), and two previously described oxylipins (2–3). Turneroic acid (1) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds 1–3 inhibited bacterial biofilm formation in Staphylococcus epidermidis, while only 3 showed antimicrobial activity against planktonic S. epidermidis. Comparison of the bioactivity of 1–3 with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition. |
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| Keywords: | anti-biofilm oxylipins Staphylococcus epidermidis Lyrodus shipworm Teredinibacter turnerae |
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