Hierarchical genetic organization of human cortical surface area |
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Authors: | Chen Chi-Hua Gutierrez E D Thompson Wes Panizzon Matthew S Jernigan Terry L Eyler Lisa T Fennema-Notestine Christine Jak Amy J Neale Michael C Franz Carol E Lyons Michael J Grant Michael D Fischl Bruce Seidman Larry J Tsuang Ming T Kremen William S Dale Anders M |
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Affiliation: | Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA. |
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Abstract: | Surface area of the cerebral cortex is a highly heritable trait, yet little is known about genetic influences on regional cortical differentiation in humans. Using a data-driven, fuzzy clustering technique with magnetic resonance imaging data from 406 twins, we parceled cortical surface area into genetic subdivisions, creating a human brain atlas based solely on genetically informative data. Boundaries of the genetic divisions corresponded largely to meaningful structural and functional regions; however, the divisions represented previously undescribed phenotypes different from conventional (non-genetically based) parcellation systems. The genetic organization of cortical area was hierarchical, modular, and predominantly bilaterally symmetric across hemispheres. We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns. |
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