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Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice |
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| Authors: | Weisstaub Noelia V Zhou Mingming Lira Alena Lambe Evelyn González-Maeso Javier Hornung Jean-Pierre Sibille Etienne Underwood Mark Itohara Shigeyoshi Dauer William T Ansorge Mark S Morelli Emanuela Mann J John Toth Miklos Aghajanian George Sealfon Stuart C Hen René Gingrich Jay A |
| Institution: | Department of Biology, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA. |
| Abstract: | Serotonin 5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment. |
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