| 几种辅料对紫杉醇脂质体粒径及Zeta电位的影响 |
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| 引用本文： | 侯巍,王淑君,孙宽,王敏,王东星,刘巍巍. 几种辅料对紫杉醇脂质体粒径及Zeta电位的影响[J]. 安徽农业科学, 2011, 39(26): 15965-15967 |
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| 作者姓名： | 侯巍 王淑君 孙宽 王敏 王东星 刘巍巍 |
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| 作者单位： | 沈阳药科大学中药学院,辽宁沈阳,110016;沈阳药科大学药学院,辽宁沈阳,110016;沈阳药大药业有限公司,辽宁沈阳,110023;沈阳格林制药有限公司,辽宁沈阳,110164 |
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| 摘 要： | [目的]探讨处方中几种辅料的加入对紫杉醇（Tax）脂质体粒径大小及Zeta电位的影响。[方法]采用薄膜分散-超声法制备Tax脂质体,利用正交设计筛选出Tax脂质体的最优处方,并测定Tax脂质体的粒径及Zeta电位。[结果]脂质体粒径及稳定性与处方中所加油酸钠等辅料有显著关系,且随着辅料量的增加,脂质体粒径变小,Zeta电位值降低,稳定性提高。[结论]油酸钠等辅料能显著降低Tax脂质体粒径及Zeta电位值。采用优选工艺制备的Tax脂质体包封率高,粒径均匀,稳定性好。
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| 关 键 词： | 紫杉醇 脂质体 正交设计:粒径 Zeta电位 |
Effect of Several Materials on the Particle Size and Zeta Potential of Tax Liposome |
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| HOU Wei et al. Effect of Several Materials on the Particle Size and Zeta Potential of Tax Liposome[J]. Journal of Anhui Agricultural Sciences, 2011, 39(26): 15965-15967 |
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| Authors: | HOU Wei et al |
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| Affiliation: | HOU Wei et al(School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016) |
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| Abstract: | [Objective] To identify the effect of several materials on the particle size and Zeta potential of Tax liposome l.[Method] Tax liposome was prepared with film dispersion-ultrasound method,the orthogonal experiment was adopted to screen out the optimum formulation of Tax liposome,and detect the particle size and Zeta potential of Tax liposome.[Result] The particle size and stability of liposome was significantly influenced by the materials such as eunatrol,and with the increasing amount of those materials,th... |
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| Keywords: | Paclitaxel Liposomes Orthogonal design Partical size Zeta potential |
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