| 结直肠癌表观遗传学研究进展 |
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| 引用本文： | 王莉莉,雷蕾,杨进.结直肠癌表观遗传学研究进展[J].广西农业生物科学,2014(1):200-204. |
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| 作者姓名： | 王莉莉 雷蕾 杨进 |
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| 作者单位： | 西北大学生命科学学院预防基因组医学研究所,西安710069 |
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| 基金项目： | 国家自然科学基金（批准号：81272707）资助 |
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| 摘 要： | 近年来,结直肠癌（colorectal cancer,CRC）成为影响人类健康的常见恶性肿瘤之一。目前对CRC发病机制的研究不仅停留在对核基因组的研究,更多集中在表观遗传学对疾病的影响,如DNA的甲基化、组蛋白乙酰化、基因印迹等对疾病发生发展过程的影响。本文主要讲述了CRC的表观遗传学研究进展,旨在探讨表观遗传学在CRC风险预警和治疗中的潜在作用。
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| 关 键 词： | 结直肠癌 表观遗传学 甲基化 乙酰化 |
Overview of Colorectal Cancer Epigenetics |
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| Wang Lili,Lei Lei,Yang Jin.Overview of Colorectal Cancer Epigenetics[J].Journal of Guangxi Agricultural and Biological Science,2014(1):200-204. |
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| Authors: | Wang Lili Lei Lei Yang Jin |
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| Institution: | ( Institute of Genome-based Preventive Medicine, Life Sciences School of Northwest University, Xi＇an, 710069) |
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| Abstract: | Colorectal cancer （CRC） has become one of the most common malignant tumors that threats human health in recent years. Most studies ofCRC pathogenesis not only focused on nuclear genome, but also on the effects of epigenetic modification such as DNA methylation, histone acetylation and gene imprinting, in CRC development and progression. This paper aimed to review the research progress ofCRC epigenetics in recent years, and to discuss the significance of epigenetics in CRC risk warning and treatment. |
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| Keywords: | Colorectal cancer Epigenetic Methylation Acetylation |
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