| Study on the Antitumor Effects of Low—energy Laser Irradiation Combined with Cyclophosphamide |
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| 引用本文： | HUANG Bao xu 1,WANG Hong bin 1,QU Zhi na 2,LIU Huan qi 1,LIU Xi feng 1,CHENG Shao hui 1 (1 College of Veterinary Medicine,North Agricultural University,Harbin,Heilongjiang,150030,PRC) (2 Animal Quarantine of Agricultural Ministry,Qingdao,266032,Heilongjiang PRC). Study on the Antitumor Effects of Low—energy Laser Irradiation Combined with Cyclophosphamide[J]. 东北农业大学学报(英文版), 2003, 10(1): 43-48 |
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| 作者姓名： | HUANG Bao xu 1 WANG Hong bin 1 QU Zhi na 2 LIU Huan qi 1 LIU Xi feng 1 CHENG Shao hui 1 (1 College of Veterinary Medicine North Agricultural University Harbin Heilongjiang 150030 PRC) (2 Animal Quarantine of Agricultural Ministry Qingdao 266032 Heilongjiang PRC) |
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| 作者单位： | HUANG Bao xu 1，WANG Hong bin 1，QU Zhi na 2，LIU Huan qi 1，LIU Xi feng 1，CHENG Shao hui 1 (1 College of Veterinary Medicine，North Agricultural University，Harbin，Heilongjiang，150030，PRC) (2 Animal Quarantine of Agricultural Ministry，Qingdao，266032，Heilongjiang PRC) |
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| 基金项目： | National Natural Science Foundation( NO:3 0 170 712 ) |
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| 摘 要： | 1 Introduction Surgery,irradiation and chemical treatment are three main therapies in treating cancers,and thesethree treatments usually combined together to obtain better effects,but irradiation and chemical treatmentcan cause immunosuppressive effects.The relationship between tumor,body,irradiation and chemical treat-ment is very complicated.How to protect immunity of the body and kill tumor at the most has become akey problem in treating malignanttumor.It was proved that proper dosages…
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| 关 键 词： | 环磷酰胺 抗癌活性 抗肿瘤药物 低能激光器照射 联合应用 疗效 腹部肿瘤 光动力疗法 |
Study on the Antitumor Effects of Low-energy Laser Irradiation Combined with Cyclophosphamide |
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| HUANG Bao-xu,WANG Hong-bin,QU Zhi-na,LIU Huan-qi,LIU Xi-feng,CHENG Shao-hui. Study on the Antitumor Effects of Low-energy Laser Irradiation Combined with Cyclophosphamide[J]. Journal of Northeast Agricultural University, 2003, 10(1): 43-48 |
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| Authors: | HUANG Bao-xu WANG Hong-bin QU Zhi-na LIU Huan-qi LIU Xi-feng CHENG Shao-hui |
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| Abstract: | Systematic experiments about the antitumor effects of low-energy laser irradiation combined with the traditional antitumor medicine of cyclophosphamide were conducted using the experimental model of mouse S180 ascites sarcoma.The three groups of tumor bearing mice were irradiated upon the inner corners with the dosages of 11.00,14.67 and 22.00 J*cm-2 LELI respectively,and injected with CYT intraperitoneally to observe the changes of the survival time,the ascites growth speed,and the kinetic changes of immune functions.The survival times of the three groups of CYT/LELI combination were obviously longer than those of the tumor and CYT control groups.Correspondingly,the amounts of ascites,tumor cells densities and total tumor cells in CYT/LELI groups decreased significantly,while the death ratio of the tumor cells increased.Comparatively,the group of 22.00 J*cm-2 LELI combined with CYT showed the most ideal antitumor effects,and the life prolongation ratio was up to 53.20%. |
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| Keywords: | Low energy laser irradiation (LELI) cyclophosphamide(CYT) antitumor effects mouse S180 ascites sarcoma |
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