Changes in hepatic enzyme activities in transgenic mice carrying human prototype c-Ha-ras gene treated with diethylnitrosamine |
| |
Authors: | Arai Toshiro Ogawa Takashi Nakamura Masako Hosoya Masaru Ohnishi Yasuyuki |
| |
Affiliation: | Division of Veterinary Biochemistry, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan. |
| |
Abstract: | Activities of malate dehydrogenase (MDH) and aspartate aminotransferase in the malate-aspartate shuttle were significantly increased in the cytosolic fractions of livers with early neoplastic symptoms such as swelling and discoloration in transgenic mice carrying the prototype human c-Ha-ras gene, Tg-rasH2 mice, which were administered with diethylnitrosamine (DEN) as a carcinogenic chemical at a dose of 200 mg/kg body weight. Cytosolic MDH/LDH (lactate dehydrogenase) (ML) ratio increased significantly and was considered to be a useful marker to characterize the energy metabolism at early neoplastic stage in livers of the Tg-rasH2 mice. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|