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| 影响马立克氏病毒感染的因素及疫苗免疫策略 | |
| 引用本文： | 王桂军,秦爱建,韦平.影响马立克氏病毒感染的因素及疫苗免疫策略[J].中国畜牧兽医,2006,33(11):73-77. |
| 作者姓名： | 王桂军 秦爱建 韦平 |
| 作者单位： | 1. 扬州大学江苏省动物预防医学重点实验室,扬州,225009;安徽农业大学动物科技学院,合肥,230036 2. 扬州大学江苏省动物预防医学重点实验室,扬州,225009 3. 广西大学禽病研究室,南宁,530005 |
| 摘 要： | 马立克氏病毒是高度细胞结合性、嗜淋巴组织的α疱疹病毒,其致病过程包括淋巴细胞的溶细胞感染和潜伏感染以及易感鸡体内CD 4 T细胞的致瘤性转化。宿主的遗传抗性、细胞免疫、体液免疫以及相关细胞因子和淋巴细胞等对M DV的感染过程有重要影响。针对M D肿瘤抗原的靶向免疫应答的保护性抗原分子和宿主细胞因子疫苗是今后疫苗研究的方向。 |
| 关 键 词： | 马立克氏病毒 感染 细胞因子 疫苗 免疫 |
| 文章编号： | 1671-7236（2006）11-0073-05 |
| 收稿时间： | 2006-05-15 |
| 修稿时间： | 2006-05-15 |
Factors Influenced the Infection of Marek's Disease Virus and the Strategy for Vaccine Development and Vaccination |
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| WANG Gui-jun,QIN Ai-jian,WEI Ping.Factors Influenced the Infection of Marek''''s Disease Virus and the Strategy for Vaccine Development and Vaccination[J].China Animal Husbandry & Veterinary Medicine,2006,33(11):73-77. | |
| Authors: | WANG Gui-jun QIN Ai-jian WEI Ping |
| Institution: | 1. Key Lab of Jiangsu Preventive Veterinary Medicine, Yangzhou University, Yangzhou 225009, China 2. College of Animal Science and Technology, Anhui Agricultural University, Heifei 230036, China; 3. Institute of Poultry Science and Health, Guangxi University, Nanning 530005, China |
| Abstract: | Marek's disease virus is a highly cell-associated,lymphotropic a-herpesvirus and its pathogenesis is involving cytolytic and latent infection of lymphoid cells and oncogenic transformation of CD4~ T cells in susceptible chickens.Genetic resistance of host,cell-mediated immunity,humoral immunity and other cytokines and lymphocytes associated with immune responses have great effects on infection of marek's disease virus.The selection of protective antigenic molecules,the incorporation of genes that encode the host's own cytokine molecules targeting immune responses to MD tumor antigens are new research directions in future. |
| Keywords: | marek's disease virus infection cytokine vaccine vaccination |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |