| 查尔酮的结构修饰及抗癌、抗炎活性研究进展 |
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| 引用本文： | 李湘洲,郭远良,旷春桃,贺义昌. 查尔酮的结构修饰及抗癌、抗炎活性研究进展[J]. 中南林业科技大学学报(自然科学版), 2011, 31(2) |
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| 作者姓名： | 李湘洲 郭远良 旷春桃 贺义昌 |
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| 作者单位： | 中南林业科技大学材料科学与工程学院; |
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| 基金项目： | 国家科技部“十一五”科技支撑计划重点项目(2006BAD18B0404); 教育部博士点基金(20094321110001); 湖南省教育厅重点项目(08A084); 湖南省科技计划项目(2007NK3119); 长沙市科技局重点项目(K0802109-21) |
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| 摘 要： | 查尔酮类化合物是广泛存在于自然界中一种黄酮类化合物,具有抗癌、抗炎症、抗菌、抗寄生虫、抗病毒等生物活性,是一类很具有前途的药物模板。重点阐述了近年来查尔酮类化合物的抗癌、抗炎症活性以及构效关系研究进展。结果表明查尔酮类化合物药理活性广泛、安全、结构简单且制备方便,是一个良好的药物开发先导物。
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| 关 键 词： | 查尔酮 抗癌 抗炎症 构效关系 |
Research progress of the anti-cancer,anti-inflammatory activities of chalcone as bioactive plant constituents |
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| LI Xiang-zhou,GUO Yuan-liang,KUANG Chun-tao,HE Yi-chang. Research progress of the anti-cancer,anti-inflammatory activities of chalcone as bioactive plant constituents[J]. , 2011, 31(2) |
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| Authors: | LI Xiang-zhou GUO Yuan-liang KUANG Chun-tao HE Yi-chang |
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| Affiliation: | LI Xiang-zhou,GUO Yuan-liang,KUANG Chun-tao,HE Yi-chang(School of Materials Science and Engineering,Central South University of Forestry &Technology,Changsha 410004,Hunan,China) |
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| Abstract: | Chalcone,which are abundant in plants as a class of flavonoids,are confirmed to possess a diverse array of pharmacological activities and considered as a promising template for drug design.The studying progress on anticancer,anti-inflammatory activities of chalcone,and the structure-activity relationship(SAR)was summarized.The findings indicate that chalcone has widely pharmacology activity,safety,simple structure,preparation convenient,and is a kind of good primer for drug development. |
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| Keywords: | chalcone anti-cancer anti-inflammatory structure-activity relationship(SAR) |
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