| 地塞米松与肝素对HL－60细胞增值和生物大分子合成的影响 |
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| 引用本文： | 张小娜,梁念慈,潘毅生.地塞米松与肝素对HL－60细胞增值和生物大分子合成的影响[J].湛江医学院学报,1995(1). |
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| 作者姓名： | 张小娜 梁念慈 潘毅生 |
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| 作者单位： | 广东医学院药理学教研室，广东医学院生物化学教研室，广州白云山制药股份有限公司 |
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| 摘 要： | 用地塞米松（Ｄｅｘ）和肝素（Ｈｅｐ）Ｉｃ６０及Ｉｃ５０低一个剂量，对ＨＬ－６０细胞增殖、生长曲线和分裂指数均有明显的抑制作用，联合应用时抑制作用显著增强；对ＤＮＡ和蛋白质合成抑制作用大于ＲＮＡ，联合应用抑制作用均显著增强，提示两药抑制ＨＬ－６０细胞增殖、分裂和生长可能与它们抑制ＤＮＡ和蛋白质合成有关，亦与抑制ＲＮＡ合成有一定关系。
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| 关 键 词： | 地塞米松 肝素 HL－60细胞 细胞增殖 DNA RNA 蛋白质 |
EFFECTS OF DEXAME THASONE(DEX)AND HEPARIN(HEP)ON PROLIFERATION AND BIOMACROMOLECULAR SYNTHESIS IN HUMAN PROMYELOCYTIC LEUKEMIA CELLS(HL-60)IN VITRO |
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| Zhang Xiaona,Liang Nianci,Pan Yisheng.EFFECTS OF DEXAME THASONE(DEX)AND HEPARIN(HEP)ON PROLIFERATION AND BIOMACROMOLECULAR SYNTHESIS IN HUMAN PROMYELOCYTIC LEUKEMIA CELLS(HL-60)IN VITRO[J].Journal of Guangdong Medical College,1995(1). |
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| Authors: | Zhang Xiaona Liang Nianci Pan Yisheng |
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| Abstract: | The proliferation,growth curve and mitotic index of human promyelocytic leukemia cell(HL-60)in vitro were markedly inhibited by Ic50 doses and lower doses of Dex and Hep.The effects of the combined Dex and Hep were stronger than the effects of Dex or Hep alone.Inhibitory effects of Dex and Hep on syntheses of DNA and protein were stronger than on the synthesis of RNA,the effects of combination was markedly stronger than the effects of Dex or Hep alone on DNA,RNA and protein synthesis.Inhibitory effects of Dex and Hep on proliferation, mitosis and growth of HL-60 cell were paralled with the inhibitory effects on the syntheses of DNA and protein.These results suggest that inhibitory effects of Dex and Hep on HL-60 cell may be related to inhibition of syntheses of DNA and protein,also to inhibited synthesis of RNA in some degree. |
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| Keywords: | Dexamethasone Heparin HL-60 cell Cellular Proliferation DNA RNA Protein |
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