Antinociceptive effect and acute toxicity of the essential oil of Hyptis fruticosa in mice |
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| Authors: | Menezes Igor A C Marques Maxsuel S Santos Thiago C Dias Kellyane S Silva Aline B L Mello Iderjane C M Lisboa Ana C C D Alves Péricles B Cavalcanti Sócrates C H Marçal Rosilene M Antoniolli Angelo R |
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| Affiliation: | 1. Physiology Department, Federal University of Sergipe, São Cristovão, Brazil;2. Chemistry Department, Federal University of Sergipe, São Cristovão, Brazil |
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| Abstract: | The essential oil of the Hyptis fruticosa leaves was analyzed by GC/MS and evaluated for antinociceptive property as well as acute toxicity in mice. The essential oil, at doses of 100, 200, and 400 mg/kg (s.c.), produced significant inhibition of acetic acid-induced writhing, but did not manifest a significant effect in hot-plate test. There was no acute toxicity at doses up to 5 g/kg. Bicyclogermacrene, 1,8-cineole, alpha-pinene, and beta-caryophyllene were the major compounds detected in the essential oil. |
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| Keywords: | Hyptis fruticosa Essential oil Antinociceptive |
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