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Modeling biological rhythms in failure time data
Authors:Naser B Elkum  James D Myles
Affiliation:(1) Department of Biostatistics, Epidemiology, and Scientific Computing, King Faisal Specialist Hospital & Research Center, Riyadh, 11211, Saudi Arabia;(2) Clinical Statistics, Pfizer Global Research and Development (PGRD), Ann Arbor Laboratories, Ann Arbor, MI 48105, USA
Abstract:

Background  

The human body exhibits a variety of biological rhythms. There are patterns that correspond, among others, to the daily wake/sleep cycle, a yearly seasonal cycle and, in women, the menstrual cycle. Sine/cosine functions are often used to model biological patterns for continuous data, but this model is not appropriate for analysis of biological rhythms in failure time data.
Keywords:
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