Familial po1ycystic kidnev disease in bull terriers |
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| Authors: | A K Burrows R Malikt† G B HuntS‡ T Davey T L W Rothwells§ W F Robinson |
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| Institution: | *School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150, Australia;†Department of Veterinary Clinical Sciences, The University of Sydney, New South Wales 2006, Australia;‡Department of Veterinary Anatomy, The University of Sydney, New South Wales 2006, Australia;§Department of Veterinary Pathology, The University of Sydney, New South Wales 2006, Australia |
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| Abstract: | Polycystic kidney disease was observed in eight related bull terriers. Two dogs died suddenly, two were presented for haematuria, while the remainder were outwardly normal but detected during ultrasonographic screening programmes. A definitive diagnosis was made at either necropsy or using renal ultrasonography, although affected dogs also had abnormal urinalyses with haematuria, proteinuria, cast formation and sometimes bacterial infection. Valvular heart disease was detected clinically or at necropsy in all the affected dogs. The presence of polycystic kidney disease in several related dogs suggests that this condition is familial. The disease has clinical and pathological similarities with autosomal dominant polycystic kidney disease of humans. |
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