Protective effect of Ginkgo biloba extract on testicular tissue of diabetic rats |
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| Authors: | MAO Sun-zhong CHEN Guo-rong LEI Kang-fu LI Xu-sheng WANG Fang LI Jian-min FANG Zhou-xi HU Yun |
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| Institution: | 1. Department of Biochemistry, Wenzhou Medical College, Wenzhou 325027, China;
2. Department of Pathology, First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325027, China;
3. Laboratory of Electron Microscope, Wenzhou Medical College, Wenzhou 325027, China |
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| Abstract: | AIM: To investigate the protective effect of Ginkgo biloba extract (GBE) on diabetic testis and explore its possible mechanism. METHODS: Testicular structure of streptozotocin-induced diabetic rats was observed under light microscopy (LM) and transmission electron microscopy (TEM). Content of malondialdehyde (MDA), NO2-/NO3- and activity of superoxide dismutase (SOD), nitric oxide synthase (NOS) were determined in testicular homogenate. RESULTS: In diabetic rats, it was manifestated as deformation of seminiferous tubule, atrophy and shedding of germinal epithelium under LM, while expansion of smooth endoplasmic reticulum, formation of fatty vacuoles and decrease of lysosome obviously in the cytoplasm of sertoli cell under TEM, the injury of testicular tissue was improved by GBE. Compared with diabetic rats, activity of SOD increased while activity of tNOS and iNOS, content of MDA and NO2-/NO3- decreased in GBE-treated rats. CONCLUSION: GBE could effectively prevent the development of diabetic testis and the effect may be partly achieved by resisting lipid peroxidation,restraining the activity of testicular tissue iNOS and reducing the pathological alterations of NO. |
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| Keywords: | Diabetes mellitus experimental Testis Lipid peroxidation Nitric oxide Ginkgo biloba |
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