首页 | 本学科首页   官方微博 | 高级检索  
     检索      


The protective effects of angiotensin Ⅱ receptor blocker irbesartan on kidney function in diabetic rats
Authors:CHEN Yan-ming  ZENG Long-yi  WU Wei-kang  ZHANG Guo-chao  JIANG Bo-quan  LUO Han-chuan
Institution:1. Department of Endocrinology, The Third Affiliated Hospital of Zhongshan University, Guangzhou 510630, China; 2. Department of Pathophysiology, Sun Yat-sen Medical College of Zhongshan University, Guangzhou 510089, China
Abstract:AIM: To investigate the effects and mechanisms of irbesartan, one of the angiotensin Ⅱreceptor blockers, on kidney function in diabetic rats. METHODS: Forty adult male Wistar rats were randomly divided into four groups: control group, diabetes group, irbesartan group and captopril group. At the end of 12 weeks, the rats were sacrificed. Urine volume, body weight, kidney weight/body weight, plasma, glucose, glycosylated hemoglobin (HbA1c), urinary β2-microglobulin (β2-MG) excretion, urinary albumin excretion rate (UAR), creatinine clearance (Ccr) were measured. Nitric oxide (NO) and endothelin-1 (ET-1) levels in plasma, urinary and renal tissues were determined. RESULTS: Urine volume, kidney weight/body weight, plasma glucose, HbA1C, UAR, Ccr, urinary β2-MG excretion, NO and ET-1 levels of urinary, blood and renal tissue in diabetic rats were significantly higher than those of normal controls ( P<0.01). UAR, Ccr, urinary β2-MG excretion, ET-1 and NO levels of urinary and renal tissue in rats of irbesartan and captopril groups were significantly lower than those of DM rats ( P<0.01). There were positive relationships among the levels of plasma, urinary, renal tissue ET-1, NO and UAR, Ccr and urinary β2-MG excretion. CONCLUSION: Irbesartan could prevent from the injury of renal function in STZ-induced diabetic rats. And it maybe one of the most importan mechanisms that irbesartan could reduce the NO and ET-1 levels in STZ-induced diabetic rats.
Keywords:Diabetes mellitus  Rats  Irbesartan  Captopril  Nitric oxide  Endothelin-1  
点击此处可从《园艺学报》浏览原始摘要信息
点击此处可从《园艺学报》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号