Effect of BCG on experimental asthma in a guinea pigmodel of allergen sensitization |
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Authors: | LIU Jin-bao ZHONG Nan-shan LI Shu-nong LIANG Zhong-pei WANG Gui-fang WU Wei |
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Affiliation: | 1. Department of Pathophysiology, Guangzhou Medical College, Guangzhou 510182, China;2. Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College, Guangzhou 510182, China;3. Department of Pathophysiology, Sun Yet-sen University of Medical Sciences, Guangzhou 510089, China |
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Abstract: | AIM: To examine the effect of bacillus calmette-guerin (BCG) on experimental asthma in guinea pigs. METHODS: Guinea pigs were sensitized with BCG and then with ovalbumin (ip). Two weeks later, guinea pigs were challenged with ovalbumin (OVA) aerosol inhalation. Thirty one Guinea pigs were divided into three groups at random control group,OVA-treated group, BCG and OVA-treated group.RESULTS: Ovalbumin inhalation caused a marked airway infiltration of eosinophils and all the animals exhibit asthmatic symptoms. Pretreatment with BCG induced typical increase in lymphocytes and monocytes in peripheral blood and in bronchoalveolar lavage fluid (BALF). BCG markedly inhibited eosinophil infiltration and attenuated the asthmatic symptoms. CONCLUSION: These data suggest that BCG exerts an inhibitory effect on asthmatic inflammation. |
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Keywords: | BCG vaccine Asthma Guinea pigs |
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