Structure,function and signal transduction of vascular endothelial growth factor receptor-2 |
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Authors: | LIU Ji-yan WEI Yu-quan |
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Affiliation: | Key Laboratory of Biotherapy of Human Diseases, West China Hospital, Sichuan University, Chengdu 610041, China |
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Abstract: | Angiogenesis, or the formation of new blood vessels out of pre-existing capillaries, is very important in many physiologic and pathologic processes, such as embryonic development, cancer, retinopathies, etc. Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a key role in angiogenesis. In this review, we discussed the structure, function and signal transduction of vascular endothelial growth factor receptor-2. Understanding these should provide important insights into how new strategies can be devised to interfere in the physiologic and pathologic processes involved in angiogensis. |
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Keywords: | Angiogensis pathologic Receptors vascular endothelial growth factor Signal transduction |
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